Niacina
When taken at doses greater than the RDA, niacin confers an array of health benefits. Niacin:
– Increases high-density lipoprotein (HDL) by 20-35%. No other available over-the-counter treatments, and very few drugs, are as effective.
– Decreases small low-density lipoprotein (small LDL) particles. Small LDL is an important yet underappreciated cause of heart disease. Niacin is the most effective agent known for correcting this abnormal pattern.
– Decreases triglycerides by 30%. Niacin is especially effective when taken with fish oil (at doses of 4000 mg a day, providing 1200 mg of EPA/DHA).
– Decreases very low-density lipoprotein (VLDL) particles.
– Decreases lipoprotein(a), or Lp(a). No other treatment approaches the power of niacin to reduce the genetically determined pattern of high Lp(a), which is among the most serious risk factors for heart disease.
– Decreases low-density lipoprotein (LDL), usually by 20-40 mg/dL, or 5-25%.
– Niacin blocks the release of fatty acids from fat cells. Fewer fatty acids are passed through to the liver, resulting in fewer VLDL particles. Less VLDL leads to less small LDL and higher HDL.1 Niacin also improves endothelial function and nitric oxide synthase activity.
Niacin’s benefits are not limited to its influence on blood markers of cardiovascular disease risk. It also reduces heart attack risk dramatically.
Fuente: https://www.lef.org/magazine/mag2007/mar2007_atd_01.htm
Reduccion de la mortalidad en un 11%: http://www.wellnessresources.com/studie … mortality/
The Coronary Drug Project was conducted between 1966 and 1975 to assess the long-term efficacy and safety of five lipid-influencing drugs in 8,341 men aged 30 to 64 years with electrocardiogram-documented previous myocardial infarction. The two estrogen regimens and dextrothyroxine were discontinued early because of adverse effects. No evidence of efficacy was found for the clofibrate treatment. Niacin treatment showed modest benefit in decreasing definite nonfatal recurrent myocardial infarction but did not decrease total mortality. With a mean follow-up of 15 years, nearly 9 years after termination of the trial, mortality from all causes in each of the drug groups, except for niacin, was similar to that in the placebo group. Mortality in the niacin group was 11% lower than in the placebo group (52.0 versus 58.2%; p = 0.0004). This late benefit of niacin, occurring after discontinuation of the drug, may be a result of a translation into a mortality benefit over subsequent years of the early favorable effect of niacin in decreasing nonfatal reinfarction or a result of the cholesterol-lowering effect of niacin, or both.
No hay que confundir Niacin con Niacinamide, los dos some Vit B3, pero el segundo es toxico para el higado en cantidades superiores a 3g/dia.
La niacina es la que te produce el flush del que hablaba en el hilo de Nootropicos (Te pones rojo, pica, esquece… Pero despues ahhhh que bien te quedas!).
A mi me pasa como a este pero todavia no soy tan adicto… http://www.lowcarbfriends.com/bbs/vitam … iacin.html
I’ve been using niacin for about 30 years. I really like the flush, because after it I feel very rested. It’s also very helpful to take niacin at night before I go to sleep, because then I always wake up feeling rested – which doesn’t always happen if I don’t take niacin.
Also, I haven’t had a mosquito bite in 30 years. I think they find the scent of niacin hard to take. Mosquitos don’t land on me, even when they are everywhere.
My question is about the amount of niacin I take. I usually take 3000 mg at a time, since I no longer get a flush with lower amounts. (And my flush is not difficult or long-lasting. Just makes me feel relaxed.) Occasionally I take up to 6000 mg a day. (If I’m really tired or if I can’t get to sleep, I’d take 3000 doses twice in that day.)
Lo de los mosquitos no lo he probado pero lo hare… Me encanta la sensacion de despues del flush de niacina, el flush en si es un poco incomodo, para nada del otro mundo!
Para mi 250mg van de sobra… de hecho tengo un buen flush con 125mg tambien pero el efecto despues no es tan intenso, el flush de 500mg me parece un tanto excesivo.
Al parecer la Niacinamide inhibe la SIRT1 (ohhh no!) no hay que tomarlo a la vez con Resveratrol (suplementos-vitaminas-f114/resveratrol-t1514.html#p6676)…
Pero…
We all know that niacinamide inhibits SIRT1.
Being about Niacin like supplements, this thread can be connected to the Resveratrol vs. CR saga, where NAD+ plays a very important role.
RSV is being presented (and sold) as a CR mimetic. I don’t think it is. In CR, as compared to "normal" diet, less NAD+ is being used in processing glucose. The spared NAD+ is utilized in deacetylation and other life extending processes.
In contrast, by taking RSV, one doesn’t spare or increase the amount of NAD+. What RSV does is to lower the Michaelis constant for deacetylation. It probably works on other pathways also.
CR mimetics should be based on NAD+ precursors or agonists. According to the latest edition of "The Complete Idiot’s Guide to Deacetylation", the Sirtuins act as facilitators (enzymes). But NAD+ are needed to close the deal.
Lo que nos lleva a: suplementos-vitaminas-f114/nicotinamide-riboside-t1593.html
Perturbing the metabolism of NAD+, either by PARP inhibition or by nicotinic acid or NAM supplementation, can extend liderada. Schmeisser et al. show that longevity requires NAM methylation by NNMT and subsequent oxidation of MNA, the methylated product, by AOx1. NAD+ metabolism also affects mitochondrial biogenesis and mitonuclear balance, resulting in activation of the mitochondrial unfolded protein response (UPRMT) and transient production of ROS. Transient ROS production by either the AOx1 reaction or by mitochondria results in SKN-1/NRF2 and DAF-16/FOXO activation, promoting longevity.
Informacion detallada sobre el "flush" de niacina:
http://molpharm.aspetjournals.org/conte … 4.full.pdf
He seguido experimentando con la niacina, si la consumes habitulamente el efecto disminuye rapidamente, pero en cuanto pasas unos pocos dias sin consumirla el efecto (flush) vuelve a ser como la primera vez.
A mi mujer le encanta para dormir, el efecto relax post-flush le permite dormir mucho mejor.
Por lo que he leido online, el flush (vasodilatacion) es algo sano y saludable, y el consumo frecuente de niacina esta relacionado con una menor mortalidad, por otro lado no existe una cantidad conocida toxica para los humanos.
1. Niacin Lowers Cholesterol Levels
2. Vitamin B3 and the Prevention of Atherosclerosis
3. Niacinamide and the Prevention of Diabetes
4. Vitamin B3 as Treatment for Osteoarthritis
Niacin is also appreciated for its anti-inflammatory effect, which makes it a proper treatment for rheumatoid arthritis. Worn down cartilage is rebuild when sufficient vitamin B3 is taken.
Fuente: http://www.fitday.com/fitness-articles/ … cin.html#b
Un hilo interesante sobre el tema: http://curezone.com/forums/am.asp?i=1923208