Metformina
Un familiar que es cardiologo toma metformina habitualmente, he estado mirando un poco:
https://www.lef.org/featured-articles/m … osage.html
There have been no human studies to identify the optimal dose of metformin that is needed to duplicate the beneficial gene expression effects.
For people who want to derive the many proven health benefits of metformin…
Sobre la restriccion calorica: https://www.lef.org/magazine/mag2003/20 … io_01.html
Caloric restriction (CR) is the most effective method of slowing aging, preventing diseases such as atherosclerosis, diabetes and cancer, and extending maximum life span in mammals. Since the 1930s, studies in rats, mice, monkeys and other species, have demonstrated that CR can maintain life, health and youth in animals for extended periods of time.
An unprecedented medical breakthrough
The discovery that a clinically-used drug (metformin) produces genetic effects similar to those of caloric restriction, including life span extension, is an unprecedented breakthrough in medicine, with astonishing implications for us all. For thousands of years, the medical profession has strived to prevent and treat killer diseases, but has never been able to find a method of intervening in the aging process.
Advances in sanitation, nutrition and medicine have increased life expectancy to a considerable degree. In the year 1900, the average life span in the U.S. was only 47 years. By 2000, it had risen to the high 70s. This has led to increasing numbers of people reaching advanced ages, but has had no impact whatever on the maximum age reached by the oldest of the old. Today, it is still very rare for anyone to live beyond the age of 107, although increasing numbers of people reach 100. In ancient Greece, the average life span was in the early 20s, but the longest lived people still reached 100+.
In the U.S. today, the average 50-year-old woman survives to age 81. If we were to conquer the two leading causes of death-cancer and heart disease-it would only extend the woman’s life span to 88, and these added years would be a time of declining health and vigor. If we were to slow aging, on the other hand, the woman would not only be less likely to die of cancer, heart disease and other killers, but would also be healthier, more vigorous and more youthful. She would live to well over 100, with the prospect of a much longer, healthier life span from later advances in the control of aging. (Fig. 1)[1]
An authentic advance in aging control would, in just a few short years, produce more health and longevity benefits than have yet been produced in the history of the planet. It would break through the hitherto impenetrable barrier that has kept every person on Earth in chains since the beginning of time. Just as the ability to leave Earth’s orbit gave us the possibility of reaching the moon, the planets, other star systems and galaxies, the ability to extend the healthy human life span would give us the possibility of living in good health well beyond the current maximum human life span.
Anti-Diabetic Drug Slows Aging and Lengthens Lifespan, Animal Study Suggests
A Belgian researcher, writing in the Proceedings of the National Academy of Sciences, reveals that metformin, the world’s most popular anti-diabetes drug, could actually slow the aging process and increase lifespan. In an isolated study, metformin was found to increase the number of toxic oxygen molecules released into cells, which made the cells themselves stronger and more resistant to breakdown over time.
Type 2 Diabetics Can Live Longer Than People Without the Disease
Scientists at Cardiff University have reported in Diabetes, Obesity and Metabolism the unexpected finding that certain diabetes medications such as metformin could offer protective benefits to healthy individuals without diabetes. In a study of 180,000 subjects, the researchers found anti-cancer and anti-cardiovascular disease properties, as well as the reduction of the chance of developing type 2 diabetes by up to one-third. In short, this finding seems to suggest that effectively controlling blood glucose could have profound benefits regardless of diabetic status.