Inductores de la telomerasa
Se ha hablado mucho de que la telomerasa podria ser la clave para rejuvencer, hay estudios muy prometedores al respecto!
This is the approximate loss of telomeres over the course of a lifetime:
Conception: 15,000 units
At birth: 10,000 units (a loss of 5,000 units)
At death: 5,000 units (a loss of another 5,000 units over the course of a lifetime)Researchers at Harvard-affiliated medical centers genetically manipulated mice to age faster, and then used gene therapy to lengthen telomeres — compounds found at the ends of strands of DNA — which reversed age-related problems such as decreased brain function and infertility.
"We at best expected it to be a slowing of the process or perhaps an arresting of the process. We did not anticipate that it would be so dramatic a reversal in all of the problems that the animal was experiencing," said Dr. Ronald DiPinho, professor of medicine and genetics at Dana-Farber Cancer Institute and Harvard Medical School, and co-author of the paper published Sunday in the journal Nature. "We were so struck by the findings that we rushed to get the study published."
Previous studies suggest that even in humans, shorter telomeres may be associated with age-related diseases such as heart disease and Alzheimer’s disease.
In fact, the brains of the age-modified mice were 75 percent of the size of a normal brain, much as happens in a patient with Alzheimer’s disease. But when researchers reactivated the telomerase, the brains returned to a normal size, according to the study.
Como podemos generar telomerasa para rejuvenecer? Esa es la gran pregunta… Astragalus?
Hilo al respecto: http://www.longecity.org/forum/topic/52 … -inducers/
Un comentario que explica mucho:
Today I would still say that the best verified telomerase activator is astragalus root, taken at about 33 grams/day, or astragalus root extract taken at about 11 grams/day. Astragalus root extract, rubbed into the scalp for a year, can often change one’s hair color back to normal. I use colostrum both internally and externally in solution on the skin, although I am uncertain about how well it gets through the skin. Colostrum contains many telomerase-activating factors. Quite a bit of astragalus root extract can be taken. Astragalus root extract in glycerin is delicious, and harks back to the days when the rejuvenating effects of astragalus root were discovered in China, when natives were brewing quite a bit of the extract and serving it up as Root Beer. Experimental dogs can tolerate very large quantities of astragalus extract well.
Exercise boosts 14 endogenous telomerase activators and improves levels of cyclic AMP, which can help restore senescent cells to normal form in the presence of EGF and/or PDGF from exercise or colostrum. It helps to take creatine monohydrate (I recommend 6 STAR creatine X3 in tablets) to synthesize cyclic AMP from ATP while exercising. Exercise also boosts levels of HIF-1 transcription factor, especially when taking ginkgo biloba. HIF-1 works to improve hTERT transcription in every cell of the body.
Also, secretagogue supplements can be taken to boost the 14 different telomerase activators from exercise.
Another exciting telomerase activator that is easy to get and promising is milk thistle extract (silymarin), taken at 10 grams/day, according to the Product B people. Nitric oxide at 5-10 grams/day is a good telomerase activator for the endothelial lining, and Hawthorn, which improves heart muscle tone, is a good telomerase activator, according to the Product B folks at IsAGenix, who have put many telomerase activators into Product B.
Otherwise, it turns out that tissues derived from mesenchymal cells, such as connective tissues, cartilage, and bone, express hTERT and hTR poorly unless a histone deacetylase inhibitor like Tricostatin A, sodium butyrate, or L-carnitine is used to expand the cellular chromatin for transcription. Perhaps sodium butyrate, which is available as a supplement, is the best choice: it is used in chicken feed to produce giant-sized chickens. L-carnitine, which is made from methionine (from fish) and lysine in the presence of vitamin C, has just recently been identified as a histone deacetylase inhibitor (HDAC inhibitor). When the chromatin is expanded, conventional telomerase activators work better to produce hTERT and hTR transcripts to rejuvenate the cell by building longer telomeres, which produces a more youthful pattern of gene transcription in the cell.