Alzheimer

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Alzheimer’s Test Detects Disease Decade Ahead of Onset
Nov 17, 2014 http://www.bloomberg.com/news/2014-11-1 … onset.html

A new blood test for Alzheimer’s appears to detect the disease as many as 10 years before clinical diagnosis is possible — far sooner than other tests in development.

The test, described publicly for the first time yesterday, could soon be used to identify and treat patients with Alzheimer’s earlier in their disease progression. Those people could participate in clinical trials to help find new treatments. Already, the test distinguishes between patients and healthy elderly with 100 percent accuracy.

Two other potential Alzheimer’s blood tests were announced earlier this year. One measures 10 fats in the bloodstream that appear to predict dementia with 90 percent accuracy within three years of its onset. Another uses 10 proteins in the blood to predict onset with 87 percent accuracy within a year.

At the National Institute on Aging, Kapogiannis and his team identified a single protein in the brain involved in insulin signaling, called IRS-1, that appears to be defective in Alzheimer’s patients.