Muy interesante, muchas gracias por la aportación!
The reason the body has multiple, redundant aging clocks is to assure that natural selection can’t defeat aging by throwing a single switch. That means the clocks must be at least somewhat independent. Nevertheless, I judge it is likely that there is some crosstalk among clocks, because that’s how biology usually works. To effect rejuvenation, we will have to address all aging clocks, but we see some benefit from resetting even one, and expect more significant benefit from resetting two or more.
The most challenging target is the epigenetic clock,built on a homeostasis of transcription and signaling among hundreds of hormones that each affect levels of the others. Reverse engineering this tangle will be a bear.
The idea of a centralized aging clock in the hypothalamus seems far more accessible, and is promising for the medium term. Still, it does not suggest immediate application to remedies. The hypothalamus is deep in the brain, and you and I might be reluctant to accept a treatment that required drilling through the skull. A treatment based on circulating proteins and RNAs from the hypothalamus would be less invasive, but even that might have to be intravenous, and include some chemistry for penetrating the blood-brain barrier. RNA exosomes seem to be our best opportunity
As Cavadas’s group has already pointed out, it is inflammation in the hypothalamus that is amplified by signaling to become most damaging to the entire body. This raises the interesting question: could it be that the modest anti-aging power of NSAIDs is entirely due to their action within the brain? In other words, maybe “inflammaging” is largely localized to the hypothalamus.