Telomeros

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Este espacio únicamente pretende ser informativo, divulgativo y de opinión; y en ningún caso sustituir al criterio médico cualificado, ni sugerir o proporcionar terapias de ningún tipo.
firehand
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Registrado: 02 Sep 2012 05:29

Re: Telomeros

Mensajepor firehand » 12 Jul 2015 22:54

Parece que hay estudios para todos los gustos, en este otro se dice que:
Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General Population Individuals with Repeat Measurements 10 Years Apart


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953026/

Vamos, que nada de lo que se creía realmente afecta! Y en este otro se confirma lo que puse más arriba:
Telomere Length and Long-Term Endurance Exercise: Does Exercise Training Affect Biological Age? A Pilot Study


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530492/

Curiosamente hace unos meses miré los resultados del ultraman 2014 y los grupos de edad me llamaron la atención:

M20-29
1 Keith Bergh 27

M30-39
1 Tobias Winnemoeller 35
2 Nick Logan 33
3 Andre Kajlich 35
4 Valenti Sanjuan 33
5 John Howerton 34
6 Matthew Phelan 37

F30-39
1 Yasuko Miyazaki 37
2 Julie Shelley 38
3 Sylvia Ravaglia 37
Stacey Shand 35

M40-49
1 Craig Percival 43
2 Peter Kotland 42
3 Gary Wang 46
4 Juan Craveri 46
5 Scott James 46
6 Pedro Paixao 41
7 Antonio Nascimento 44
8 Roland Patzina 48
9 Ernest Castella 45
Jochen Dembeck 47 M
Brian Fredley 46 M

F40-49
1 Kathy Winkler 48
2 Meredith Terranova 40
3 Iona Mackenzie 42
4 Vanuza Maciel 44
Karen Brown 46

M50-59
1 Tony Okeeffe 53
2 Miro Kregar 52
3 Peter Mueller 52
4 Kevin Becker 50
5 Giancarlo Matarazzo
6 Martin Raymond 52
7 Stephen Cosgrove
8 Tony Horton 51

F50-59
1 Kat Calder-becker 23
2 Dene Sturm 50

F60-69
1 Laurie Beers 60

Casi todos entre los 40 y los 60 años! Teniendo en cuenta que el pico físico masculino está en los 35 más o menos, sorprende que casi todos los clasificados sean > 40.

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Dalamar
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Registrado: 09 May 2012 01:38

Re: Telomeros

Mensajepor Dalamar » 01 May 2016 21:25

Fuente: http://www.longevityreporter.org/blog/2 ... inst-aging

The CEO of Bioviva USA Inc., Elizabeth Parrish, became the first person to undergo rejuvenative gene therapy in 2015, and results are now out - the procedure successfully lengthened her telomeres by the equivalent of 20 years

We covered Bioviva's and Elizabeth Parrish's pioneering efforts in October (check out the article here). Of the two therapies she received in 2015, one was telomerase gene therapy which aims to increase levels of the enzyme telomerase which extends telomere length. As you get older your telomeres gradually wear down which compromises stem cell activity, and there have been numerous studies supporting telomere shortening as a major contributor to the aging process. Many scientists believe that correcting the loss could rejuvenate and protect against aging. Telomerase gene therapy in mice (see here) had both of those effects, with mice living on average 24% longer. Mice are all well and good, but we need human testing and that's what Elizabeth Parrish and Bioviva wanted to kickstart.

It worked.

Parrish's initial telomeres were measured by SpectraCell in Houston and revealed to be unusually short for her age, which placed her at higher risk of age-related disease as a number of studies have hinted that telomere length is a good biomarker of overall health. We all start off with different lengths so the rate of shortening seems to be more important than the overall length, but it still remains a good indicator of disease risk. Parrish underwent gene therapy in September 2015, and in March 2016 the telomeres in her white blood cells were measured again by SpectraCell. They had extended from 6.71kb to 7.33kb, which corresponds to around 20 years of aging. These results were independently verified by UK based charity The Biogerontology Research Foundation, and Brussels based non-profit company HEALES (Healthy Life Extension Company.

Parrish: “Current therapeutics offer only marginal benefits for people suffering from diseases of aging. Additionally, lifestyle modification has limited impact for treating these diseases. Advances in biotechnology is the best solution, and if these results are anywhere near accurate, we’ve made history”

Exciting stuff!
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Dalamar
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Re: Telomeros

Mensajepor Dalamar » 11 Jun 2016 08:17

Fuente: http://www.longevityreporter.org/blog/2 ... -therapy-1

Mice With Hyper Long Telomeres Created Without Gene Therapy: Mice with doubly long telomeres have been created, without altering the telomerase gene. They also exhibit lessened DNA damage, greater repair capability and even reduced tumour incidence
.
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Dalamar
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Re: Telomeros

Mensajepor Dalamar » 04 Oct 2016 20:07

Tuesday, October 4, 2016

On August 22, 2016 the Journal of Human Nutrition and Dietetics published a report by researchers at Kookmin University in Seoul, Korea which revealed an association between increased consumption of specific micronutrients and longer telomere length.

Telomeres, which shorten with aging, are regions of DNA that cap and protect the ends of chromosomes. Longer telomere length has been associated with a reduction in the risk of age-related diseases that include diabetes, coronary heart disease and dementia.

The current investigation included 1,958 participants in the ongoing Korean Genome Epidemiology Study aged 40 to 69 years upon enrollment between 2001 and 2003. Dietary questionnaire responses were analyzed for the amount of vitamins A, B1, B2, B3, B6, C and E, folate, calcium, phosphorus, potassium, iron and zinc consumed. Leukocyte (white blood cell) telomere length was assessed at the ten-year follow-up examination.

Adjusted analysis uncovered an association between greater intake of vitamin C, folate and potassium with longer telomere length, which further analysis determined was significant only among those who were younger than 50 years upon enrollment—a finding that the authors suggest could be due to a lower intake of these nutrients among older subjects

Authors J.-Y. Lee and colleagues note that the ability of antioxidants' such as vitamin C to modify the balance between antioxidant and antioxidative response could influence telomere length, and add that a greater intake of vitamins C and E from the diet or multivitamins has been associated with longer telomere length in women. Specific B vitamins that include folate play a role in telomere maintenance due to their participation in DNA repair, methylation and chromosome maintenance in one-carbon metabolism pathways. While the mechanism supporting potassium in telomere maintenance is less clear, the mineral is present in fruit and vegetables, which, when consumed in higher amounts, have been associated with longer telomere length in previous studies.

"Our findings are supportive, to a certain degree, of the hypothesis that earlier consumption of antioxidant nutrients and B-vitamins involved in one-carbon transfer pathways is associated with longer leukocyte telomere length, suggesting the effects of nutrient intake on biological aging," Dr Lee and colleagues write.

"We found longitudinal associations of vitamin C and folate, as well as potassium intake, with leukocyte telomere length among middle-aged and older adults," they conclude. "However, further studies are necessary to determine the causal relationship between the consumption of these nutrients and changes in telomere length. In addition, whether the use of vitamin C and folate supplements can help maintain telomeres is not known and warrants further study."
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Dalamar
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Re: Telomeros

Mensajepor Dalamar » 04 Dic 2016 19:05

Prometedor...

In April 2016 BioViva stated that Elizabeth Parrish, CEO, had experienced telomere lengthening in her leukocytes, as a result of an injection of two experimental therapies. These consisted of a myostatin inhibitor to protect against loss of muscle mass with age, and a telomerase inducer to battle stem cell depletion responsible for diverse age-related diseases and infirmities. While the test was designed to establish the first human safety data regarding telomerase induction, in tests conducted by SpectraCell Laboratories, data indicated that her leukocyte telomeres had lengthened by approximately 20 years, from 6.71kb to 7.33kb. Further data will be released later this year. Upon further examination and testing, comparison of Parrish's data prior to the therapy and following the therapy has revealed additional positive changes. MRI scans taken before and after depict a slight increase in muscle size in conjunction with a noticeable reduction in muscle fat content. An over-accumulation of intramuscular fat, also known as 'marbling', is associated with increased insulin resistance, and as such an appropriate reduction may be linked to beneficial metabolic changes, in addition to the improved musculature. The aforementioned patient's total body weight has also not decreased during this period, and as such weight loss is not a confounding variable. The muscle growth achieved post-therapy corresponds with observed improvements in patients with Becker's Muscular Dystrophy, after receipt of myostatin inhibition gene therapy.

Researchers have noted that a significant reduction in fasting glucose was apparent in mice following telomerase gene therapy. The subject's fasting glucose has declined from previous measurements of 94 mg/dL and 86 mg/dL, to a fasting glucose level of 71 mg/dL by August 2016, as measured by Quest Diagnostics. Repeated testing will confirm the implied increase in insulin sensitivity. Previous research has also indicated that telomerase deficiency impairs glucose metabolism and insulin secretion in telomerase deficient mice, which may explain an apparent improvement in metabolic markers. In accordance with an improvement in metabolic health, triglyceride levels have also declined from 140 mg/dL in 2015 prior to the therapy, to 36 mg/dL in February 2016, subsequently rising to 80 and 84 mg/dL in August 2016. While there has been an increase in blood triglyceride content following the February reading, it is still measurably lower than before treatment. Both decreases in fasting glucose and triglycerides can be potentially explained by prior studies, of both telomerase and myostatin. Raised myostatin mRNA seen in type 2 diabetes patients is associated with impaired insulin sensitivity, raising triglyceride levels and low-grade chronic inflammation. Myostatin inhibition in mice has also been shown to reduce triglyceride levels and improve insulin sensitivity.

No negative effects have been reported, and there are no visible detrimental effects in blood analysis thus far; providing tentative evidence of safety in the first human test of BioViva's dual gene therapy strategy.
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Dalamar
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Re: Telomeros

Mensajepor Dalamar » 21 Ene 2017 07:01

Lack Of Exercise In The Elderly Women Leads To Shorter Telomeres: Elderly women who sit more than 10 hours a day and fail to get at least 40 minutes of daily exercise are at risk of increased telomere shortening.

Nearly 1,500 women, ages 64 to 95, participated in the study. The women are part of the larger Women's Health Initiative (WHI), a national, longitudinal study investigating the determinants of chronic diseases in postmenopausal women. The participants completed questionnaires and wore an accelerometer on their right hip for seven consecutive days during waking and sleeping hours to track their movements. "We found that women who sat longer did not have shorter telomere length if they exercised for at least 30 minutes a day, the national recommended guideline. Discussions about the benefits of exercise should start when we are young, and physical activity should continue to be part of our daily lives as we get older, even at 80 years old."


En este caso el estudio es solo en mujeres y de edad avanzada, no se sabe en otros casos...
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Dalamar
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Re: Telomeros

Mensajepor Dalamar » 04 Mar 2017 06:47

Un infografico sobre los telomeros
Adjuntos
Telomeros.png
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