Telomeros

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Dalamar
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Telomeros

Mensajepor Dalamar » 21 Oct 2014 05:04

Los telómeros son estructuras especializadas situadas en los extremos de los cromosomas, que los protegen de posibles fusiones y de su degradación, con lo que se garantiza la estabilidad de los cromosomas y viabilidad de las células. No obstante, los telómeros se van acortando progresivamente asociado al proceso de división celular ya que el ADN que forma los telómeros no es replicado de manera completa.

    Los telómeros protegen a los cromosomas de actividades de degradación y de la fusión de cromosomas
    Los telómeros protegen la integridad de los cromosomas permitiendo la generación de una réplica completa de los extremos del ADN cromosómico gracias a la actividad de una enzima: la telomerasa, que es capaz de sintetizar telómeros de novo
    Asimismo, los telómeros hacen posible una ubicación correcta de los cromosomas en el núcleo celular

El azúcar y el tabaco acortan los telomeros:

Epel and her team analyzed data from 5,309 adults in the National Health and Nutrition Examination Survey (NHANES) from about 14 years ago. They found that people who drank more sugary soda tended to have shorter telomeres. Drinking an 8-ounce daily serving of soda corresponded to 1.9 years of additional aging, and drinking a daily 20-ounce serving was linked to 4.6 more years of aging. The latter, the authors point out, is exactly the same association found between telomere length and smoking.

Or more specifically:

After adjustment for sociodemographic and health-related characteristics, sugar-sweetened soda consumption was associated with shorter telomeres (b = –0.010; 95% confidence interval [CI] = −0.020, −0.001; P = .04).
Regular consumption of sugar-sweetened sodas might influence metabolic disease development through accelerated cell aging.
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Re: Telomeros

Mensajepor Dalamar » 01 Nov 2014 09:03

Ejercicio + Meditacion/Yoga + Dieta rica en vegetales baja en grasas (Con mucho O3) y baja en harinas y azucares = Telomeros mas largos!

As most of you that read Vince Giuliano’s blogs know, there has been a great deal of interest in telomere lengthening as a way of living longer. In 2013, a landmark study was published that unfortunately went largely unnoticed (Ornish, 2013). In a paper published in August, 2013, Dean Ornish and Elizabeth Blackburn showed that you can lengthen telomeres by 10% over 5 years without pills by merely altering your diet, exercising, and managing your stress. (Even the expensive astragalus supplement made by TA Sciences has been unable to lengthen telomeres. It only reduces the rate of telomere shortening). Elizabeth Blackburn won the 2009 Nobel Prize with Carol Greider and Jack Szostack for discovering telomerease in tetrahymena.

I think she is a much more credible source of information than the astragalus supplement industry. In this small study, Dean Ornish put a group of elderly males with low grade prostate cancer on a diet that was low in fat (10% of calories), was plant-based (vegan), was high in whole grains, fruits, vegetables, legumes, and was low in refined carbohydrates. (They also had to take one serving of tofu per day and a soy protein powder drink, a selenium supplement, Vitamin C, fish oil, and Vitamin E). They also walked for 30 minutes a day, 6 days per week. The stress management, program including 60 minutes of yoga-based stretching, breathing, meditation, imagery, and progressive relaxation 6 days a week. They also participated in a one hour support group once a week. The study was a 5-year prospective clinical trial with a control group who did not do the above. At the end of the clinical trial, telomere lengths were measured in blood leukocytes and noted to be 10% longer than at the beginning of the trial. On the other hand, the control group had telomeres that were 3% shorter than at the beginning of the trial. This is a remarkable study, considering that no prior study and no supplements have been shown to lengthen telomeres (only reduce the rate of shortening). None of the above interventions are expensive and are not supplement based, except for the selenium, Vitamin C, fish oil, and Vitamin E. (Although it has been shown that exercise and fish oil can affect telomere length, the results of this trial cannot be explained by the fish oil supplements or exercise alone). The conclusion of this study is consistent with the scientific data that supports the idea that telomere length is NOT a biological clock that keeps accurate “biological age” but instead, telomere length is another measure of oxidative stress and that oxidative stress can be managed with lifestyle.
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Re: Telomeros

Mensajepor Dalamar » 18 Nov 2014 20:27

Un tipo que afirma que ha rejuvenecido al tomar diversos suplementos, en especial activadores de la telomerasa:

http://greenray4ever.com/pics2013dec31.html

Mucho que leer....
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Re: Telomeros

Mensajepor Dalamar » 18 Nov 2014 21:19

Los telomeros cortos activan enfermedades... Muy interesante! Tendremos que alargarlos un poco!

Telomere Looping Activity Influences Aging and Disease Onset
UT Southwestern Medical Center researchers, writing in the journal Genes and Development, reveal how a “looping” process in DNA telomeres can turn certain genes off at a young age but turn them back on as a person ages and lead to disease onset. This looping mechanism in younger cells appears able to keep certain genes from expressing because the telomere itself is long enough to influence them. As the telomere shortens over time, however, it can’t “loop” far enough to regulate potentially disease-causing genes. More research into telomere function could lead to a variety of new ways to prevent age-related disease.
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firehand
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Re: Telomeros

Mensajepor firehand » 11 Jul 2015 21:58

The findings, to be presented at the Australian Society for Medical Research National Conference, found ultra-marathon runners clocking up 40-100 km a week had 11 per cent longer telomeres.

"This 11 per cent difference adds 16 years to your life expectancy," Prof Charchar said.

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Re: Telomeros

Mensajepor Dalamar » 12 Jul 2015 05:27

Muy interesante! Yo ya habia leido que el deporte es importante para los telomeros, pero ahi se ve claramente.. ahora la pregunta es, si realmente esa gente envejece mas despacio o hay otros factores como es de esperar.
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Kaizen
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Re: Telomeros

Mensajepor Kaizen » 12 Jul 2015 10:31

A modo resumen gráfico, lo que he visto en cuanto a nutrientes que ayuden a tener unos telomeros grandes son estos:

Imagen

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Dalamar
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Re: Telomeros

Mensajepor Dalamar » 12 Jul 2015 15:02

Pues eso son muy buenas noticias, yo me pongo hasta arriba de todos ellos! E en concreto en forma de Tocotrienols.
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Re: Telomeros

Mensajepor Dalamar » 12 Jul 2015 18:59

Por lo que leo, los atletas que sobre-entrenan habitualmente tienen telomeros mas cortos en los musculos.

Athletes with exercise-associated fatigue have abnormally short muscle DNA telomeres.

Y es una condicion que puede ser permanente. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581416/
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Re: Telomeros

Mensajepor Kaizen » 12 Jul 2015 20:13

Dalamar escribió:Por lo que leo, los atletas que sobre-entrenan habitualmente tienen telomeros mas cortos en los musculos.

Athletes with exercise-associated fatigue have abnormally short muscle DNA telomeres.

Y es una condicion que puede ser permanente. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581416/


Interesante! Y la pregunta es, con lo que dijo y expuso firehand, no hay una contradicción?

firehand escribió:
The findings, to be presented at the Australian Society for Medical Research National Conference, found ultra-marathon runners clocking up 40-100 km a week had 11 per cent longer telomeres.

"This 11 per cent difference adds 16 years to your life expectancy," Prof Charchar said.



Porque los ultra atletas, lo que hacen es pegarse palizas, literalmente. Y digamos que eso debería ser considerado sobre-entrenamiento.


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