Probioticos

Reglas del Foro
Este espacio únicamente pretende ser informativo, divulgativo y de opinión; y en ningún caso sustituir al criterio médico cualificado, ni sugerir o proporcionar terapias de ningún tipo.
Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 20 Abr 2014 15:12

Los antibioticos son los peores enemigos de tu microbiota: http://chriskresser.com/the-high-price- ... ly-recover

One study found that after a single treatment of intravenous antibiotics, fecal bacteria tests demonstrated a significant change in the variety of bacterial strains, and the development of the pathogen Clostridium difficile. C. difficile colonization in the gut can lead to serious complications such as severe diarrhea and colitis.

Another study demonstrated that a short course of the antibiotic ciprofloxacin reduced the diversity of the intestinal microbiota, with significant effects on roughly one-third of the bacterial species. This study also found that while much of the diversity eventually recovered, there were still several species that failed to recover after six months, suggesting that even a short course of antibiotics may cause permanent changes to the community of friendly flora in the gut.

Research also indicates that infants’ gut flora is significantly affected by cesarean delivery, which requires the administration of antibiotics to the mother.

Resident bacteria of the normal flora are involved in intestinal mucosal inflammation and patients with inflammatory bowel disease (IBD) have higher amounts of bacteria attached to their intestinal mucosa than do healthy people. (11) Patients with Crohn’s disease and ulcerative colitis are found to have reduced concentrations of fecal Lactobacillus and Bifdobacteria, which protect against pathogenic bacteria, increase mineral absorption and induce the production of growth factor in the gut.

An unbalanced microbiota in the gut is also a contributing factor in autoimmunity. Infection with certain microbial pathogens can trigger autoimmune reactions in joints and other organs. The destruction of healthy gut flora can make the mucosal lining more susceptible to leakage, which some researchers believe is a precondition for developing autoimmunity. It is well-established that the balance of gut bacteria plays a key role in the formation of a proper immune response. A lack of healthy gut bacteria is associated with allergies, IBD, and general autoimmune reactions when this immune modulation goes awry.

New research has linked changes in gut bacteria with obesity.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 20 Abr 2014 15:22

Los antibioticos incrementan el riesgo de cancer: http://www.ncbi.nlm.nih.gov/pubmed/1870 ... stractPlus

Un blog interesante sobre la microbiota: http://intestinalgardener.blogspot.ae
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 20 Abr 2014 15:48

El transplante fecal, es la formula para devolver la diversidad a la microbiota...

Fecal transplant, do it yourself:

http://download.journals.elsevierhealth ... 000698.pdf

Fecal microbiota transplantation in relapsing Clostridium difficile infection:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491681/

http://www.muyinteresante.es/salud/arti ... digestivas
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 20 Abr 2014 15:52

Artritis y la microbiota: http://www.muyinteresante.es/salud/arti ... 1383738662

La microbiota o conjunto de microorganismos que coexisten en nuestro cuerpo es un arma de doble filo. Al tiempo que nos ayuda a digerir los alimentos y los gérmenes infecciosos, también está implicada en las reacciones alérgicas y la obesidad. La lista de inconvenientes se amplía tras esta investigación, según la cual sería el desencadenante de desórdenes autoinmunes como la artritis reumatoide, un trastorno en el que el propio cuerpo ataca a los tejidos de las articulaciones.

El equipo de investigadores analizó muestras fecales (que reflejan la población de bacterias intestinales) de 114 residentes del área de Nueva York. Algunos sujetos estaban sanos, mientras que otros padecían artritis reumatoide. Este segundo grupo estaba dividido en quienes habían sido tratados y quienes no. Los resultados mostraron que los pacientes sin tratamiento portaban en un 75 % de los casos una bacteria llamada Prevotella copri. Esta fue cultivada en el laboratorio e introducida en ratones para comprobar que, en efecto, producía inflamación intestinal, si bien no directamente artritis.


Y la microbiota en la obesidad: http://www.muyinteresante.es/salud/arti ... 1378456182

Los investigadores demostraron también que extrayendo bacterias fecales de deposiciones de gemelas adultas en las que una de las hermanas era obesa y otra delgada, y trasplantando los gérmenes en roedores, los ratones con microbios de individuos obesos ganaban más peso que los que recibían bacterias de sujetos delgados. "En otras palabras, la ganancia de peso se puede transmitir de humanos a ratones a través de sus microbios digestivos", concluye Rob Knight, coautor del estudio que publica la revista Science y que podría conducir a un nuevo remedio frente al sobrepeso y la obesidad.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 20 Abr 2014 16:41

Aqui nos dicen: http://chriskresser.com/all-about-fecal ... ransplants

So, all these poor people who don’t really quite understand that particular aspect are taking stool from a friend or a loved one, putting it into an ordinary kitchen blender, blending it up in the presence of oxygen and perhaps not quite the right liquid medium, and almost instantly they’re killing 90% of the bacteria that would have been available. When you don’t know precisely which one you’re missing, I cannot understand why you’d take the risk of killing 90% and hoping that the one you need is in the remainder. Then subsequent mishandling of the rest of the process means that people are getting exposed to a very, very small amount of what they need.


Donde hacerte un transplante fecal y cuanto cuesta? Yo he encontrado este de momento: http://taymount.com/treatment-fees/

Es en Reino Unido (Hitchin) y sale entre 2000 a 4000 libras para los tratamientos mas comunes, de 3 a 10 FMTs, cada FMT se hace un dia diferente, por lo que hay que calcular la estancia en consecuencia.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 01 May 2014 20:13

“Is our modern germaphobic lifestyle doing us more harm than good?”

The gist of the article that followed was that we spend an extraordinary amount of time and money on antibiotics and chemicals trying to eradicate “bad” bacteria. But at the same time, we’re destroying the “good” bacteria in our microbiomes that help protect us from pathogens, help feed us, and have recently been shown to play fundamental roles in normal human development. Even some of the “bad” bugs are only harmful at certain stages of our lives and actually perform beneficial functions at other stages.

In an ideal world we would be able to take out harmful bacteria and leave the good ones alone. So wouldn’t it be great if we could selectively target specific strains of bacteria—only bugs that we know are “bad” and only at a time in our lives when they cause harm—and wipe them out with a sort of “smart bomb”?

It turns out researchers at North Carolina State have developed just that capability by taking advantage of what’s known as the CRISPR-Cas system.

Eugene Koonin, from the National Center for Biotechnology Information in Bethesda, Maryland, and his colleagues proposed that bacteria (and certain other microorganisms) take up DNA from invading viruses and preserve it in their own genetic structure, where it awaits an opportunity to serve as a template for RNA molecules that can match up with foreign DNA and incapacitate the intruder.

In 2011, research teams headed by Jennifer Doudna from UC Berkeley and Emmanuelle Charpentier from the Helmholtz Centre for Infection Research in Germany joined forces and discovered how this works for one particular CRISPR system that employs the Cas protein called “Cas9.” Cas9 is a “nuclease”—an enzyme specialized for cutting DNA.

The teams found that when a phage (short for bacteriophage) invades a cell, the bacterium transcribes the spacers and the palindromic DNA into a long, matching RNA molecule—with the code pulled off a plasmid (a DNA strand produced and stored outside the nucleus, i.e., a temporary copy for current threats), or out of the cell’s own genome. From there, several pathways are available to then turn this copy into a weapon that works against the invading DNA. This CRISPR RNA (crRNA) is transformed into an effector complex, paired with a Cas9 nuclease and a nifty-sounding TracrRNA to create a killer combo that can find the offending invader and neutralize it. The Cas9 acts like scissors, slicing the hostile DNA and rendering it inert.



Fuente: Casey
Adjuntos
CRISPR.jpg
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 03 May 2014 20:11

The microbiome is made up of more than 100 trillion microorganisms living in the body, and, thanks to the explosive growth of genomics, scientists are beginning to chart just how this inner-space ecosystem affects human health. San Bruno, CA's Second Genome is among a crop of nascent biotechs working to ferret out drug targets in the microbiome, mining for therapeutic mechanisms in the gut.

Now, with Pfizer in tow, Second Genome plans to study 900 people with varying metabolic phenotypes, working to better understand the relationship between microbiomic profiles and metabolic disorders, including obesity. The patient cohort, recruited by a team of researchers at Massachusetts General Hospital's cardiology wing, has already helped investigators identify a diabetes-resisting gene, and Second Genome CEO Peter DiLaura said the study could yield similar progress for obesity.

"Our relationship with Pfizer on a study of this size and magnitude is needed to potentially shift our understanding of this runaway epidemic and find fresh approaches to treating metabolic disease," DiLaura said in a statement.

And the potential is already there: Recent animal studies have established that changes in the gut microbiome can affect symptoms of metabolic disease, according to Second Genome, including a study in which the introduction of certain microbes was found to spur weight loss in mice.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 21 Jul 2014 19:22

Consuming Probiotics for a Month Helps Diminish Fat Accumulation in the Liver
Scientists at the University of Granada, writing in the journal PLOS ONE, reveal that in a study of obese laboratory rats, the consumption of probiotics for 30 days reduced the presence of fat deposits in the liver. Non-alcoholic fatty liver disease (NAFLD) is the accumulation of fat in the liver, a process called steatosis, and it’s tied to both obesity and diabetes. While probiotics don’t present a cure of any kind, treating fat deposits with healthful probiotic microorganisms could, after more testing, lead to treatment options that reduce damage to the liver.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 22 Jul 2014 16:04

Probiotics Might Help Lower Blood Pressure
Researchers at the Griffith University School of Medicine in Queensland, Australia, writing in the journal Hypertension, report that supplementing a diet with daily probiotics could help to control high blood pressure. By analyzing test subjects included in prior studies, the researchers found small but significant decreases in both systolic and diastolic blood pressure readings when about the amount of probiotic bacteria found in a container of yogurt was consumed daily for eight weeks or more. While probiotic supplementation is in no way a cure for hypertension, it could help those with the condition control it better over time.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8831
Registrado: 09 May 2012 01:38

Re: Probioticos

Mensajepor Dalamar » 25 Jul 2014 06:41

Vanderbilt University Medical Center scientists, revealing their work in the Journal of Clinical Investigation, report that probiotic supplementation helped mice in a laboratory test resist the negative biological effects of a high fat diet. This new finding follows several stories about probiotics that have appeared in this space in recent days, as compelling results continue to accumulate surrounding the usefulness and potential protective benefits of certain gut bacteria. In previous studies, probiotics were found to help inhibit insulin resistance, a finding that could pave the way for diabetes treatment breakthroughs.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!


Volver a “Salud”

Ingresar