Ayuno intermitente

Reglas del Foro
Este espacio únicamente pretende ser informativo, divulgativo y de opinión; y en ningún caso sustituir al criterio médico cualificado, ni sugerir o proporcionar terapias de ningún tipo.
Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 25 Feb 2017 09:48

Fuente: http://www.bbc.com/news/health-39070183

Fasting diet 'regenerates diabetic pancreas'

In the experiments, mice were put on a modified form of the "fasting-mimicking diet".

It is like the human form of the diet when people spend five days on a low calorie, low protein, low carbohydrate but high unsaturated-fat diet.

It resembles a vegan diet with nuts and soups, but with around 800 to 1,100 calories a day.

Then they have 25 days eating what they want - so overall it mimics periods of feast and famine.
Previous research has suggested it can slow the pace of ageing.

Diabetes therapy?

But animal experiments showed the diet regenerated a special type of cell in the pancreas called a beta cell.
These are the cells that detect sugar in the blood and release the hormone insulin if it gets too high.

Dr Valter Longo, from the University of Southern California, said: "Our conclusion is that by pushing the mice into an extreme state and then bringing them back - by starving them and then feeding them again - the cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ that's no longer functioning."

There were benefits in both type 1 and type 2 diabetes in the mouse experiments.

Type 1 is caused by the immune system destroying beta cells and type 2 is largely caused by lifestyle and the body no longer responding to insulin.

Further tests on tissue samples from people with type 1 diabetes produced similar effects.

Dr Longo said: "Medically, these findings have the potential to be very important because we've shown - at least in mouse models - that you can use diet to reverse the symptoms of diabetes.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 04 Mar 2017 13:14

A new study finds that providing the body with a temporary, specifically formulated fasting mimicking diet (FMD) called ProLon causes cellular changes normally generated by several days of consecutive water-only fasting and may increase health and lifespan by partially turning back the aging clock. After animal results showing that this FMD reduces incidence of cancer and inflammatory diseases and extends lifespan, researchers have now published the results of a 100-participant randomized Phase II clinical trial demonstrating that ProLon targets the aging process and reduces risk factors for age related diseases such as diabetes, cancer, and cardiovascular disease in humans. These effects are believed to be caused by an increase in stem cell number and regeneration.

Pre-clinical studies demonstrated that ProLon provides the body with the necessary macro and micronutrients while keeping it in a fasting mode and activates stem cell-based regeneration in multiple organs and systems. ProLon is perhaps the first success story in a new but rapidly developing nutri-technology field. The understanding of the molecular connections between specific food components and genes that regulate aging and regeneration allows food to be used to promote cellular changes that are safe but more coordinated than those caused by drugs.

Researchers tested the effects of three monthly ProLon cycles on metabolic markers and risk factors associated with aging and age-related diseases. Each ProLon cycle lasts five consecutive days and does not require alteration to lifestyle during the remaining days of the month. Findings in humans were consistent with mouse studies showing a spike in circulating stem cells and delay in biological aging by promoting regeneration in multiple systems. Body weight, BMI, total body fat, trunk fat, waist circumference, systolic and diastolic blood pressure, cholesterol, insulin-like growth factor 1 (IGF-1), and C-Reactive Protein (a marker of inflammation) were significantly reduced, particularly in participants at risk for diseases, while relative lean body mass (muscle and bone mass) was increased. Low levels of IGF-1 are associated with a lower risk of cancer and diabetes. No serious adverse effects were reported


Otro estudio:

Recent research offers one glimpse into how cutting calories impacts aging inside a cell. The researchers found that when ribosomes - the cell's protein makers - slow down, the aging process slows too. The decreased speed lowers production but gives ribosomes extra time to repair themselves. "The ribosome is a very complex machine, sort of like your car, and it periodically needs maintenance to replace the parts that wear out the fastest. When tires wear out, you don't throw the whole car away and buy new ones. It's cheaper to replace the tires." So what causes ribosome production to slow down in the first place? At least for mice: reduced calorie consumption.

Researchers observed two groups of mice. One group had unlimited access to food while the other was restricted to consume 35 percent fewer calories, though still receiving all the necessary nutrients for survival. "When you restrict calorie consumption, there's almost a linear increase in lifespan. We inferred that the restriction caused real biochemical changes that slowed down the rate of aging." The team isn't the first to make the connection between cut calories and lifespan, but they were the first to show that general protein synthesis slows down and to recognize the ribosome's role in facilitating those youth-extending biochemical changes. "The calorie-restricted mice are more energetic and suffered fewer diseases. And it's not just that they're living longer, but because they're better at maintaining their bodies, they're younger for longer as well."

Ribosomes, like cars, are expensive and important - they use 10-20 percent of the cell's total energy to build all the proteins necessary for the cell to operate. Because of this, it's impractical to destroy an entire ribosome when it starts to malfunction. But repairing individual parts of the ribosome on a regular basis enables ribosomes to continue producing high-quality proteins for longer than they would otherwise. This top-quality production in turn keeps cells and the entire body functioning well.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 16 Mar 2017 17:36

Antes comentábamos que si una persona empieza a comer menos durante un tiempo, progresivamente el cuerpo se va adaptando y reduce su metabolismo, para dejar de perder peso.

Pero eso no ocurre con el ayuno intermitente. Es decir, no comer durante 12 horas, 18 horas, 24 horas o incluso 48 horas,

Hay personas que hacen un día de ayuno a la semana.

O bien que, para perder de forma rápida mucho peso, sólo comen a días alternos.

Qué es lo que ocurre cuando ayunamos? Muchas cosas muy buenas

De entrada el metabolismo no desciende, sino que se mantiene.

La insulina se retira del todo y el cuerpo empieza a cambiar su forma de obtener energía. En lugar de quemar carbohidratos de la dieta, quema las grasas como combustible, creando los maravillosos cuerpos cetónicos.

El cuerpo piensa que, el cazador de la cueva, ha terminado con el último antílope cazado y se ha quedado sin comida. Ahora no puedo bajar el metabolismo porque necesito que este cazador salga a cazar más comida antes de que sea tarde. Con lo cual, se sacrifica la grasa y se preserva la masa muscular, que se mantiene o incluso aumenta. Es increíble, verdad? El metabolismo se mantiene intacto. Quemamos grasas a tope.

De manera que, aunque al día siguiente, para compensar, comas hasta hartarte, raramente comerás el doble o lo que habrías comido durante los dos días.

Y sin embargo, esas 12-18-24 horas en ayunas han permitido que pudieras quemar grasas sin problemas, sólo ingiriendo agua y algo de sal.


Fuente: http://lameteoqueviene.blogspot.ae/2016 ... eta-o.html
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 13 Jun 2017 06:22

A medio camino con mi tercera ronda de FMD, cada vez es mas sencillo, tengo que hacerlo consistentemente cada mes.

Cada vez reduzco mas la cantidad de calorias consumidas, antes tomaba las 1000 iniciales y 700 consecutivas, ahora reduzco al minimo, primer dia una enlada de unas 200 calorias para todo el dia, segundo dia un zumo para comer de unas 150 calorias y una ensalada con kimchi de unas 350 calorias para cenar, anaeronico ligero el segundo dia.

Hoy tratare de mantenerme en dos ensaladas de unas 200-250 calorias cada una hoy.
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 18 Jun 2017 05:44

Termine mi tercer ciclo de FMD bajando 3.5 kg en cinco dias, me noto excelente con mucha mas energia, el efecto rebote de los dias posteriores me ha hecho recuperar 1.5 kg, teniendo en cuenta que he comido sin mesura estos dias, ahora volvere a 1 o 2 ayunos semanales las proximas 3 semanas, antes de hacer otro ciclo de FMD, con estos ayunos deberia de perder en estas tres semanas, esos 1.5 kg lo que me llevaria a mi peso ideal, el FMD posterior me dejaria un par de kilos por debajo de mi peso ideal, lo cual esta bien ya que me ire de vaciones 3 semanas y sin lugar a dudas cometere excesos!
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 18 Jun 2017 05:53

Otro sistema que puede ser interesante es saltarse el deasayuno y cenar temporano, es decir comer durante un periodo de 6-8 horas, al parecer tiene benefios para la salud, dejar descansar al cuerpo es bueno en vez de tenerlo activo constantemente, poco a poco se van desmontando los mitos de muchas comidas y de que el desayuno es la comida mas importante.
Adjuntos
intermittent-fasting.jpg
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 14 Ago 2017 02:24

Se aprende más con el estómago vacio...

Learning capacity is known to decline with age, and similar effects are also associated with several neurodegenerative diseases. Regulation of insulin signaling by dietary restriction (DR) modulates lifespan in many organisms, and it has been also shown to enhance learning and memory. However, the underlying mechanisms of these processes are largely unknown due to the difficulty in disentangling the systemic effects of DR from any potentially brain-specific effects. Here, we have analyzed the molecular effects of dietary restriction in C. elegans and show that associative learning is enhanced by reducing production of the tryptophan metabolite kynurenic acid (KYNA).

KYNA is an antagonist of glutamatergic signaling in neurons, and we find that its depletion in the nervous system upon DR allows for increased activation of an interneuron that is both necessary and sufficient to mediate learning. We investigated the effects of reductions in either insulin or mTOR signaling pathways, as well as the effects of pharmacological and genetic interventions that lead to activations of AMPK and autophagy. We show that DR and these DR mimetics each result in learning enhancements. Despite their wide-ranging cellular and organismal effects, we find that the beneficial effects of each of these interventions on learning are fully dependent on reductions in KYNA.

Finally, we demonstrate that KYNA levels have no effect on organismal lifespan, indicating that the effects of this KYNA-mediated response to dietary restriction is truly specific to brain function and not a secondary consequence of improved health or longevity. As altered KYNA levels are associated with neurodegenerative and psychiatric diseases, our results suggest that this component may be an important modulator of learning and memory in humans as well
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 23 Ago 2017 06:06

The story of the strange, extracellular protein called PCSK9 has now become the focal point of a $4.5 billion/year gravy train for Big Pharma companies, due to the dramatic effect that monoclonal antibodies have of clearing this “bad” protein out of the blood. There is no debate that the use of these monoclonal antibodies has a greater effect on reducing all-cause mortality than any other drug, diet, supplement, or lifestyle intervention at this time, with an ACM reduction of 55%. However until the cost of these PCSK9 monoclonal antibodies drops below $4,536 per person per year, they are not cost effective. Since the increased expression of the PCSK9 gene is due in part to the Insulin/IGF-1 signaling pathway, which prevents FoxO3a transcription factor from migrating into the cell nucleus, the most cost effective way to reduce PCSK9 expression is to reduce your insulin levels. This can easily be done with diet and exercise. Moreover, a phytochemical from the Salvia plant called Tanshinone IIA, and SIRT6 activation with NAD+/NR/NMN may also be ways to prevent the increase in PCSK9 gene expression which are NOT due to insulin. The loss of SIRT6 activity due to the decline in NAD+ levels within the nucleus is a likely contributor to the age-related increase in PCSK9. Nevertheless, because oxidized LDL is such a powerful “driver” of atherosclerosis, a dramatic reduction in PCSK9 plasma protein levels should be a major goal for lengthening lifespan. Despite its unpopularity, fasting has been scientifically shown to be the cheapest and most effective way to reduce PCSK9. With a 48-hour fast, PCSK9 levels can be lowered by 58%, which is even more than the monoclonal antibodies do!


Mis tipicos ayunos son de 36 horas, como se puede ver en el grafico es una buena eleccion! A partir de las 12 horas de eyuno empiezan los efectos beneficiosos...
Adjuntos
PCSK9.jpg
PCSK9.jpg (31.26 KiB) Visto 249 veces
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

Avatar de Usuario
Dalamar
Site Admin
Mensajes: 8871
Registrado: 09 May 2012 01:38

Re: Ayuno intermitente

Mensajepor Dalamar » 05 Sep 2017 19:23

Estoy en pleno FMD a lo bestia... llevo 75 horas sin comer, en 15 horas más comeré una ensalada de 250-300 calorías.

Ver: https://www.theguardian.com/lifeandstyl ... is-it-safe
Adjuntos
IMG_20170905_212009.jpg
¿Te ha gustado este hilo? Compartelo en las redes sociales para que se sume mas gente a la conversacion!

JoseCas
Especulador Novato
Mensajes: 162
Registrado: 31 Dic 2015 02:29

Re: Ayuno intermitente

Mensajepor JoseCas » 05 Sep 2017 22:54

75h!wow. Yo de las 24h no paso. Que crack.
Aparte de sentirte con mas energía,perder peso,etc. ¿se han producido algunos cambios en tus analíticas?


Volver a “Salud”

cron

Ingresar